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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: A hybrid nanopharmaceutical for specific-amplifying oxidative stress to initiate a cascade of catalytic therapy for pancreatic cancer

Fig. 3

Intracellular ROS generation, MMP alteration and JAK2/STAT3 expression. A Schematic illustration of ROS causing cell apoptosis through multiple pathways (Created with www.BioRender.com). B LSCM images of intracellular ROS levels. Scale bar: 20 µm. C LSCM images of MMP changes after different treatments. Scale bar: 50 µm. D Flow cytometry analysis of MMP changes and E corresponding JC-1 aggregates/monomers percentages (n = 3). F Western blot analyses of phospho-JAK2 (Tyr 1007), STAT3, phospho-STAT3 (Tyr 705) protein levels in PANC-1 cells after different treatments

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