Fig. 5
US and MR imaging in vitro and in vivo. A In vitro US images of H2O2, SG + H2O2, SG@M and SG@M + H2O2 at different time points and B corresponding mean gray values. C In vivo US and CEUS images of tumors before and after intravenous injection of SG@M at different time points. D T1-weighted MR images of different concentrations of SG@M in the pH 7.2 and pH 6.5 containing GSH (5 mM) buffer and the relative T1 relaxation rates. E T1-weighted MR images of tumor-bearing mice before and after intravenous injection of SG@M at different time points. F The blood circulation and G accumulation within tumor tissues for Mn in tumor-bearing mice administrated SG@M (n = 3)