Fig. 5

Degree of inflammation and biodistribution of the semiconducting polymer nanoparticles in mice with acute pancreatitis. (a) Experimental scheme by which the SPN assessed severity in AP mice. (b) Changes in body weight recorded over 21 h (n = 3). (c-g) Serum analysis of TNF-α, IL-1β, IL-6, lipase and amylase in mice of different groups after i.v. injection of SPN. (h-i) Fluorescence signal of the SPN in vitro and in vivo after i.v. injection to AP mice (blue dotted line: liver, red dotted line: pancreas). (Data represent means ± SDs, *p < 0.05, **p < 0.01, ***p < 0.001.)