Fig. 6

The constructed nanoparticles inhibited the proliferation of bone metastasis and alleviated osteolysis. (A) Photographic image of bone-metastatic tumors from different treatment groups. (B) Bone-metastatic tumor weights of different treatment groups. (C) Micro-CT reconstruction images of the tumor-bearing limbs from different groups. (D) Bone volume analyses of different treatment groups. (E) H&E staining, (F) TRAP staining and (G) OCN immunohistochemical staining images of the tumor-bearing limbs from different groups. All data are presented as the mean ± SD (n = 6). *p < 0.05, **p < 0.01