Fig. 3
From: Oncogene-targeting nanoprobes for early imaging detection of tumor
Reprinted with permission from ref [74, 75, 81, 83]
(A) Scheme of oncogene-targeting PA probe for ratiometric photoacoustic imaging of thrombin and in vivo PA imaging in response to PBS and thrombin [81]; (B) Strategy of cancer-targeting theragnostics using MFAS miR-221 MB and in vivo imaging of astrocytoma-targeting theragnostics with fluorescence imaging (upper panel) and bioluminescent imaging (low panel) [83]; (C) Schematic of the SNAB technology and telomerase detection in solution and time-lapse fluorescent images of tumor in vivo tumor (red circle) and tumor-free tissue (black circle) [74]; (D) Schematic diagram of AuNPs functionalized with a dye (Cy3) labeled hairpin-DNA and Epi-fluorescence analysis of nude mice bearing orthotopic human gastric cancer cells (0.5, 4, 24, 72 and 120 h) [75].