Fig. 6

(A) Synthesis scheme of DNA tetrahedron structure of ANG-TDNs (A) [117]; (B) 3D reconstruction of in vivo imaging of TDNs (top) or ANG-TDNs (bottom) treated mice [117]; (C) In vivo fluorescent images after injecting TDNs (left) or ANG-TDNs (right) for 90 min in normal mice [117]; (D) Synthesis scheme of DNA tetrahedron structure of FA-Dy-99mTc-TDN [118]; (E) Dynamic biodistribution of monitored in the KB tumor-bearing nude mice for continuous 1 h through fluorescent imaging [118]; (F) SPECT-CT imaging of FA-Dy-99mTc-TDN in the KB tumor-bearing nude mice 2 h post injection [118]; (G) Schematic for the fabrication of the T-probe system and amplified imaging of multiplexed target with T-probe via hybridization chain reaction (HCR) [119]; (H) In vivo fluorescence images obtained in 25 min after peripheral tumor injection (left) and after tail-vein injection (right) [119].