Fig. 2

BM Sca-1⁺ exosomes improved visual behavior after retinal ischemia–reperfusion (I/R) injuries. A Schematic illustration of the apparatus for the light/dark exploration mouse model. B, C Mice who received Sca-1⁺ exosomes after I/R (I/R + Sca-1⁺ exo) were more able to respond to light exposure, compared to those who received Sca-1⁻ exosomes (I/R + Sca-1⁻ exo), or untreated post-I/R. Schematic illustration (D) and photograph (E) depicting the experimental apparatus for optomotor tests. F–H Visual behaviors, in terms of head movements, under 0.1–0.3 cycles per degree (cpd) were better preserved among I/R + Sca-1⁺ exo mice, compared to I/R and I/R + Sca-1⁻ exo. Data shown as mean ± SEM. n = 3 mice/group for all experiments. **P < 0.01, *P < 0.05