Fig. 7

Therapeutic mechanism of action of GelMA/OSSA/PMB Hydrogel in diabetic infected wounds. The top 20 items identified by GO functional enrichment of upregulated genes a and downregulated genes b. The top 20 items identified by KEGG pathway enrichment of upregulated genes c and downregulated genes (d) (fold change ≥ 2 and padjust < 0.05). The GSEA of NOD-like receptor signaling pathway e, NOD-like receptor signaling pathway f and NF-kappa B signaling pathway g. h Heat map of upregulated genes involved in Wnt signaling pathway. i Heat map of downregulated genes involved in NOD-like receptor signaling pathway and NF-kappa B signaling pathway (fold change ≥ 2 and p value < 0.05). g The protein–protein interaction (PPI) network of Wnt signaling pathway, NOD-like receptor signaling pathway and NF-kappa B signaling pathway, respectively. Statistical analysis of TNF-α k, IL-6 l, IL-1β m and MDA n during the whole phases (n = 6). Bar graphs represent mean + SD. NS, not significant; ***p < 0.001