Fig. 1

The rational design and synergistic chemo-immunotherapeutic mechanisms of 2-BP/CPT-PLNs. A 2-BP/CPT-PLNs were co-assembled from 2-BP, CPT-ss-PAEEP₁₀, and DSPE-PEG, and fabricated by the evaporation-emulsification method. B Schematic illustration of 2-BP/CPT-PLNs for chemo-immunotherapy via inducing ICD, replacing ICB via inducing PD-L1 degradation, and improving antitumor immune killing capacity of T cells in vivo