Fig. 1
Characterizations of DNA-based nanocarrier. (A) AFM characterization of the sequential constructs in the generation of the targeted DNA origami loaded with DOX and ICG (TOADI). Insets: enlarged images. (B) 1% agarose gel electrophoresis analysis of the self-assembled triangle DNA origami with AS1411; lanes 1-3: M13 scaffold, TO and TOA, respectively. (C) UV-vis-NIR spectra of TOA, DOX, ICG, TOAD, and TOADI, respectively. (D) Dynamic light scattering of TO, TOA, TOAD, and TOADI. (E) Zeta-potential analysis of TOA, TOAD, and TOADI. (TO: Triangle DNA origami; TOA: Triangle DNA origami with AS1411; TOAD: Triangle DNA origami loaded with DOX; TOADI: Triangle DNA origami loaded with DOX and ICG). The data are presented as the mean ± SD (n = 3)