Fig. 2
Loading efficiency and release of DOX and photothermal properties of DNA nanodevice. (A) Time-dependence of loading efficiency of DNA origami (20 nM) to DOX (2 mM) and ICG (1 mM). (B) DOX release profiles of TOADI at different pH values in the presence of laser irradiation (808 nm, 1.0 W/cm2, 5 min) at various time points. (C) The photothermal effect of TOADI (corresponding to DOX: 20 µM, ICG: 14 µM) under 808 nm irradiation (1.0 W/cm2), with ICG (14 µM), TOAD (corresponding to DOX: 20 µM) and PBS used as control samples. (D) Temperature evolution of ICG and TOADI dissolved in aqueous solution (ICG:14 µM) under 808 nm laser irradiation (1.0 W/cm2) after laser on/off cycles. (E) Temperature changes of TOADI dispersed in aqueous solution with various concentrations under 808 nm laser irradiation (1.0 W/cm2, 5 min). (F) Infrared thermal images at different concentrations and laser irradiation (808 nm, 1.0 W/cm2) were monitored by an infrared thermal camera in vitro. The data are presented as the mean ± SD (n = 3)