Scheme 1
Schematic illustration of the mechanism by which injectable multifunctional magnetic bone repair hydrogels (MBRs), such as Fe3O4/GOx/MgCO3@PLGA, drive mild hyperthermia-starving mutual synergistic therapy for bone tumor treatment and accelerate bone defect repair. (A) Synthesis of PLGA gels and the encapsulation of glucose oxidase and Fe3O4/MgCO3 nanoparticles. (B) Mild hyperthermia-triggered GOx release to induce starvation-magnetic synergistic therapy in 143B bone tumors. The enzymatic activity of GOx was reserved under mild thermal conditions and accelerated the enzyme-promoting reaction, and HSP70 was inhibited by simultaneously decreasing ATP for enhanced magnetic hyperthermia therapy. The irregular bone defect was repaired by the porous structure of the MBRs, enhanced osteogenic differentiation and calcium salt deposition to achieve a treatment and repair two-in-one strategy