Fig. 2
Images of neuritic plaques stained with OC antibody and labelled PLGA in the cortex. A-L; Photomicrographs of the cortex of 5xFAD mouse brains depicting localization of immunoreactive Aβ1-42 (red; A, D, G, J), fluorescent labelled native PLGA (green; B, E, H, K) and their co-localization (arrows; C, F, I, L) at 1 h (A-C), 3 h (D-F), 24 h (G-I) and 1 week (J- L) following acute administration of labelled PLGA into the brain. Note the colocalization (arrows) of fluorescent labelled native PLGA with Aβ-positive neuritic plaques labelled with OC antibody and the gradual decline of labelled PLGA with time in 5xFAD mouse brains. M-O; Photomicrographs of the cortex of wild-type (WT) control mice depicting lack of immunoreactive Aβ1-42 (M), fluorescent labelled native PLGA (N) and their co-localization (O) at 3 h following acute administration of labelled PLGA into the brain