Fig. 4
Images of neuritic plaques stained with OC antibody and labelled PLGA in the cerebellum. A-L; Photomicrographs of the cerebellum of 5xFAD mice depicting localization of immunoreactive Aβ1−42 (red; A, D, G, J), fluorescent labelled native PLGA (green; B, E, H, K) and their co-localization (arrows; C, F, I, L) at 1 h (A-C), 3 h (D-F), 24 h (G-I) and 1 week (J- L) following acute administration of labelled PLGA into the brain. Note the lack of immunoreactive Aβ-positive neuritic plaques, fluorescent labelled native PLGA and their colocalization in the cerebellum over the course of experimental timeline in 5xFAD mouse brains. M-O; Photomicrographs of the cerebellum of wild-type (WT) control mice depicting lack of immunoreactive Aβ1−42 (M), fluorescent labelled native PLGA (N) and their co-localization (O) at 3 h following acute administration of labelled PLGA into the brain