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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production

Fig. 4

DHA could bind to ROMO1 but has no inhibitory effect per se. (A-C) The binding effect of DHA with ROMO1 was analyzed by molecular docking, wherein DHA may be linked with ROMO1 through PRO-7 and GLY-9. The power of the combination was − 5.1 kcal/mol. (D) Western blot indicated no obvious changes of ROMO1 expression after DHA treatment. (E-F) The CETSA experiment further turned out that DHA possessed a binding capacity to ROMO1.

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Journal of Nanobiotechnology

ISSN: 1477-3155

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