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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production

Fig. 7

ZIF-DHA inhibited ROMO1 signaling in ovarian cancer xenografts in mice. (A) Schematic portraying the procedures of xenograft models. (B) Tumor tissues were harvested and photographed at the end of experiments. (C) The tumor growth curves in ovarian cancer xenografts treated with free ZIF, free DHA or ZIF-DHA. (D) The tumor weight in ovarian cancer xenografts treated with free ZIF, free DHA or ZIF-DHA. (E) The body weight curves in ovarian cancer xenografts treated with free ZIF, free DHA or ZIF-DHA. (F) ELISA assays were used to explore the effects of ZIF-DHA on cellular H2O2 concentration. (G-H) Immunohistochemical analysis was used to explore the effects of ZIF-DHA on the expression of ROMO1.

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Journal of Nanobiotechnology

ISSN: 1477-3155

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