Fig. 2
A Schematic design of the synthesis of biomimetic hypoxia-triggered poly(MIs)/PTX@PEI/siPGK1@CCM. B TEM morphology of poly(MIs)/PTX@PEI. C TEM morphology of poly(MIs)/PTX@PEI/siPGK1@CCM under normoxia and hypoxia. Inset: core/shell structure by TEM in high-resolution and yellow arrow indicated CCM shell. D The structural transformation mechanism of amphiphilic poly(MIs)-PEI into hydrophilic poly(MIs-NH2)-PEI by reduction of nitro (−NO2) to amine (−NH2) under hypoxic conditions catalyzed by intracellular nitroreductases. E Membrane protein visualization of poly(MIs)/PTX@PEI /siPGK1@CCM and the whole cancer cell membrane (CCM) through SDS-PAGE analysis. F Zeta potential changes of the PBS solution. G siPGK1 release behavior of poly(MIs)/PTX@PEI/siPGK1@CCM under hypoxia and normoxia (10, 20, 40, 60 min)