Fig. 6
From: Advances in PD-1 signaling inhibition-based nano-delivery systems for tumor therapy
Copyright 2016, ACS
a (upper) Schematic diagram of the self-assembly of m-HA (i), and dissociation of HA-NPs by hyaluronidase (HAase) (ii). (lower) Schematic diagram of microneedle synergistic drug delivery through the skin to the tumor site. b Average hydrodynamic dimensions and TEM imaging of self-assembled HA-NPs (Scale bar: 200 nm). c SEM imaging of MN patch and fluorescence imaging of representative MN patch containing FITC-aPD1-loaded NPs (Scale bar: 400 μm). d In vivo bioluminescence imaging of MN-treated melanoma-bearing mice at different time points and distribution of Cy5.5-labelled 1-MT in major organs 3 days after the administration of MNs formulated with aPD1 and 1-MT-HA (upper) or free 1-MT (lower). e Average tumor areas of mice in different treatment groups. Reproduced with permission from [103].