Fig. 6
Nanoliposome delivery system of AML treatment. Note: (A) The procedure of loading arsenic into liposomes, (A-a) Hydration of dried lipids, (A-b) Gel exclusion chromatography.(A-c) Addition of As2O3 solution into liposomes,(A-d) Influx of H3AsO3 into liposome, (A-e) plotted of the novel nano-liposomes. (B) TEM images of liposomes encapsulating a solution of pH 7.4 (Lip(NaCl), B-a and B-d), pH 7.1 (Lip(Ni), B-b and B-e), pH 7.2 (Lip(Co), B-c and B-f), respectively. These samples of a, b and c were stained with 4% uranyl acetate; the samples of d, e and f were unstained and the micrographs show discrete electron-dense inorganic cores within the liposomes. (C) Temperature and pH-triggered arsenic release from Lip-(Ni, As). (D) Cytotoxicity of free As2O3, Lip(Ni, As), and Lip(Co, As). (Figure source from the reference [58], color figure can be viewed at acs.org.com.)