Fig. 10

a Radiotherapy enhances the uptake of Exos that promote T cell migration into the NPC tumor microenvironment. After 24 h of treatment, the fluorescence intensity of CFSE in NPC cells was determined using flow cytometry. NPC43 or C666-1 tumor-bearing mice (n = 3 or 4) were irradiated (0 or 4 Gy) and treated with DiR-labeled Exos (30 µg/mouse) after 3 days. b CCL5 in the culture SNs of C666-1 and NPC43 cells 24 h after irradiation at 0 or 3 Gy. c Ex vivo detection (top) and analysis of DiR signals in tumor tissues (bottom). d C666-1 and NPC43 tumor-bearing Rag2^−/−γc^−/−mice (n = 5) were irradiated (0 or 4 Gy) and then intraperitoneally injected with Exos (20 µg/mouse) or Ctr. e Excised tumors, f Tumor volume, and g Tumor weight of C666-1 xenografts after treatment.