Fig. 7
From: Extracellular vesicles: a rising star for therapeutics and drug delivery
Reprinted with permission from Ref [184]
FG@PEL-based PTT for inhibiting tumor progression and lung metastasis in a 4T1 primary tumor mouse model in vivo. a Schematic diagram of FG@PEL-based PTT for inhibiting tumor progression in an H22 primary model. b–c Tumor volumes H22 tumor-bearing mice after different treatments. d Immunofluorescence assay examining the expression of GPX-4 in tumor tissues isolated from the aforementioned mice. Scale bar: 100 μm. e–f Levels of ATP, HMGB1, calreticulin, and eif-2a. g Lungs excised from 4T1 orthotopic tumor mouse models were used to evaluate the inhibitory effect of different treatments on pulmonary metastasis. H&E staining was performed on whole lungs isolated from these mice. Scale bar: 2000 μm. H&E staining of partial lung tissue. Scale bar: 100 μm.