Fig. 8
From: Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy
The synthesis of PLGA-GA2-CUR and its resultant therapeutic impact on a beagle uveitis model. A The schematic diagram illustrates the composition of PLGA-GA2-CUR. B A dynamic size distribution of light scattering describes the model particle of PLGA-GA2-CUR. C SEM provides microstructure images of PLGA-GA2-CUR. D The anti-inflammatory effect of topical PLGA-GA2-CUR is demonstrated in a canine model of acute endophthalmitis. Following an intraocular injection of lens protein at t = 0 h, the semiquantitative preclinical ocular toxicology scoring (SPOTS) was employed, incorporating scores for aqueous flare (a), pupillary light reflex (b), and conjunctival swelling (c). Local administration of PLA-GA2-CUR showed statistical significance when compared to topical prednisolone acetate (PA) and untreated controls, as assessed by two-way ANOVA. Statistical significance is denoted as *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. This figure is reproduced from Ref. [186] with permission from the American Association for the Advancement of Science