Fig. 2From: CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodelingPreparation and characterization of the nanodroplets. (A) Preparation of the nanodroplets. (B) Fluorescence microscope diagram of FH-V9302-siGLUL-NDs. Scale bars: 10 μm. (C) Transmission electron microscopy (TEM) of FH-V9302-siGLUL-NDs at a volume ratio of 1:20 ratio (siGLUL: nanodroplets). Scale bars: 200 nm. (D) FH-V9302-siGLUL-NDs size distribution. (E) Drug release of FH-V9302-siGLUL-NDs with or without ultrasound stimulation (0.5 W/cm2, 60 s, 1.0 MHz). (F) US imaging in vitro. (G) US imaging in vivo. The red circle indicates the site of the tumor. All statistical data are expressed as means ± SD (n = 3)Back to article page