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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling

Fig. 5

Safety evaluation. (A) Hemolytic behavior of Free V9302. (B) Hemolytic behavior of FH-V9302-siGLUL-NDs. (C) Hemolytic behavior of FH-NDs. (D) Statistics of hemolysis of Free V9302. (E) Statistics of hemolysis of FH-V9302-siGLUL-NDs. (F) Statistics of hemolysis of FH-NDs. (G) Agarose gel electrophoresis retardation assay of serum stability of naked siGLUL (a) and FH-V9302-siGLUL-NDs (b) in 50% fetal bovine serum. (H) Cytotoxicity of FH-NDs at different concentration in CAFs. (I) Cytotoxicity of FH-NDs at different concentration in B16F10. (J) Body weight changes of mice between treatments (n = 5). (K) H&E staining of major organs after intravenous injection of FH-V9302-siGLUL-NDs. Scale bar: 100 μm. *p < 0.05 (ANOVA test). All statistical data are expressed as means ± SD (n = 3)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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