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Fig. 9 | Journal of Nanobiotechnology

Fig. 9

From: CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling

Fig. 9

The establishment of a tumor model with co-implantation of B16F10 and CAFs cells and biodistribution assessment of nanodroplets. (A) B16F10 mixed with or without CAFs cells were injected intradermally into flanks of C57 mice, respectively. Photographs of tumor model after 10 days. (B) Statistics of tumor weight. (C) IHC staining of α-SMA. Scale bar: 200 μm. (D) Quantitative analysis of α-SMA using Image J software. (E) Masson trichrome staining. Scale bar: 200 μm. (F) Quantitative analysis of collagen deposition using Image J software. (G) Biodistribution of nanodrugs in the body 4 h after tail vein injection. (H) Quantitative analysis of biodistribution of nanodrugs in tumor. ***p < 0.0001, ****p < 0.0001(t-test). All statistical data are expressed as means ± SD (n = 3)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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