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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Nanosilicate-functionalized nanofibrous membrane facilitated periodontal regeneration potential by harnessing periodontal ligament cell-mediated osteogenesis and immunomodulation

Fig. 4

Conditioned medium from PDLCs cultured on PCL/LAP nanofibrous membranes potential induces anti-inflammatory and pro-remodeling N2 neutrophils polarization. a Schematic illustration of neutrophils treated by conditioned medium from PDLCs. b Representative appearances of neutrophils treated with different condition medium. c Heat maps of gene expression levels in neutrophils treated with condition medium from PDLCs cultured on PCL/LAP nanofibrous membranes. d-g Pro-inflammatory gene (IL-6, IFN-γ, TNF-α and NF-κB) levels of neutrophils. h-i Anti-inflammatory gene (IL-4 and IL-10) expression of neutrophils. j Pro-remodeling gene (VEGFA) expression of neutrophils. k-m Pro-inflammatory cytokines (IL-6, IFN-γ and TNF-α) levels of neutrophils. n-o Anti-inflammatory cytokines (IL-4 and IL-10) levels of neutrophils. j Pro-remodeling cytokine (VEGFA) level of neutrophils. Scale bar = 30 μm. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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