Fig. 4
Histopathologic changes in different diameters of cervical cancer. (A) Representative images of different diameters xenograft groups. (B) Representative ultrasound images of different diameters xenograft groups. (C) Pathological images of H&E staining (× 200; scale bar, 100 μm) of different groups. (D) Immunohistochemical staining to evaluate CD34-microvessel density (MVD) in different groups (× 400; scale bar, 50 μm). (E) Box-and-whisker plot of CD34-MVD in different diameters of cervical cancer. (F) Box-and-whisker plot of CD34-IOD in different diameters of cervical cancer. (** P < 0.01, *** P < 0.001, ns = nonsignificant). (G) MVD which revealed the tumor neovascularization process, was more abundant in microinvasive cervical cancer models then invasive cervical cancer. MBVEGFR2 could targetly bind to angiogenesis markers-the vascular endothelial growth factor receptor type 2 (VEGFR2) on the new microvessels