Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering

Table 1 Stimuli-responsive electrospun nanofibers as intelligent drug delivery platform in biomedicine field

Responsive material	Type of stimulus	Other polymers	Drug	Electrospinning method	Biomedicine	Ref
ICG	NIR light	CS/PVA	Doxorubicin	Blend	Treatment of cervical cancer	[54]
MoS₂	NIR light	CS/PVA	Doxorubicin	Blend	Inhibit the postoperative tumor reoccurrence	[55]
Pyrrole	NIR light	PCL/PLGA	Doxorubicin	Post-modification	Local cancer treatment following surgical resection	[56]
PNLA	Temperature	PLLA	Rifampicin	Blend	Controllable drug delivery	[57]
Fe₃O₄	Magnetic field	PCL/gelatin	Ciprofloxacin	Coaxial	Wound dressing	[58]
ZIF-8	pH	PVA	Vancomycin	Blend	Infected bone repair	[59]
Chi-AO	Electro	PVA	Dexamethasone	Blend	Tissue regeneration	[60]
GO/Au NRs and CS	NIR light/pH	PTMG-PU	Paclitaxel	Coaxial	Treatment of lung cancer	[61]
Iron oxide and Poly(NIPAAm-coHMAAm)	Magnetic field/ Temperature	/	Curcumin	Blend	Treatment of melanoma cancer	[62]
CTS-g-PNIPAAm	Temperature/pH	PEO	BSA	Blend	Drug delivery and tissue engineering	[63]
P(NIPAAm-co-AAc)	Temperature/pH	RSF	Rhodamine B	Blend	Controllable drug delivery	[64]

Abbreviations: Au NRs, Gold nanorods; BSA, Bovine serum albumin; Chi-AO, Chitosan-aniline oligomer; CS, Chitosan; CTS-g-PNIPAAm, Chitosan-graft-poly(N-isopropylacrylamide); GO, Graphene oxide; ICG, Indocyanine green; NIR, Near-infrared; P(NIPAAm-co-AAc), poly(N-isopropylacrylamide-co-acrylic acid); PCL, Poly(ε-caprolactone); PEO, Poly(ethylene oxide); PLGA, Poly (D,L-lactic-co-glycolic acid); PLLA, Poly(L-lactide); PNLA, Poly(N-isopropylacrylamide)-b-poly(L-lactide); PTMG-PU, Poly (tetramethylene ether) glycol based-polyurethane; PVA, Poly(vinyl alcohol); Poly(NIPAAm-coHMAAm), Copolymer of N-isopropylacrylamide (NIPAAm) and N-hydroxymethylacrylamide (HMAAm); RSF, Regenerated silk fibroin; ZIF-8, Zeolitic imidazolate framework-8

ISSN: 1477-3155