Fig. 10
From: Nanotechnology-based ocular drug delivery systems: recent advances and future prospects
The long-term effect of the laser-induced mice CNV model using Anti-VEGF@BetP-Gel. a Experimental design to evaluate the impact of Anti-VEGF@BetP-Gel. b Fluorescence IVIS imaging demonstrating the in vivo retention of IgG-Cy5.5 at various time periods after intravitreal injection of free IgG-Cy5.5 or IgG-Cy5.5@BetP-Gel. c H&E-stained transverse CNV sections after 4Â weeks intravitreal injection. d The typical fluorescein fundus angiography images of laser-induced mice CNV model taken at 1, 2, and 4Â weeks following intravitreal injection. e The graded and measured angiogenic vascular leakage values