Fig. 3

Differentially expressed genes (DEGs) analysis by RNA-Seq. (A) Volcano plot showing DEGs in MB49 cells between the PtPDs + L and PBS groups; DEGs: Differentially expressed genes. A red gene represents an upregulated gene, whereas a blue gene represents a downregulated gene (log 2 fold change (FC) ≤-1 and False Discovery Rate (FDR) ≤ 0.001). (B) Gene ontology (GO) enrichment analysis of DEGs; Qvalue ≤ 0.05 is considered a significant difference. (C) Expression heatmap of significant DEGs, which were laid out and classified by gene function using the NCBI NR database