Fig. 4

Biodistribution and photochemotherapy in vivo. (a) Accumulation of PtPDs in MB49 tumor was determined at different times. (b) Biodistribution of PtPDs in MB49 tumor-bearing mice was determined by ICP-MS. The major organs were extracted to evaluate the biodistribution of PtPDs 24 h after administration. (c) Photothermal capability of PtPDs at the tumor site. (d) Tumor volume and (e) Representative photographs of treated MB49-tumor bearing mice at day 16. (f) Intratumor HMGB1, (g) TNF-α, and (h) IFN-γ levels. All results represent the mean ± SD (n = 3), *p < 0.05, **p < 0.01