Fig. 4
From: Nanoparticles systemically biodistribute to regenerating skeletal muscle in DMD
MSNPs biodistributed to quadriceps after experimental-induced injury. A. MSNPs were injected 7 days post injury to right mdx quadriceps. Ex vivo NIR fluorescence imaging of limb muscles at 24 h after animals received IV injection of NIR-labeled lipid-coated 70 nm MSNPs (50 mg/kg). B. Tissue sections and graph show increase accumulation of MSNPs (white) near eMyHC (red) positive myofibers. Graph quantifies, the size and fluorescent intensity of MSNPs in BaCl2-injured and non-injured mdx quadriceps (N = 3). C. Whole body imaging of animals at 24 h after IV injection of DyLight755 labeled MSNPs