Fig. 1From: A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriersPreparation and characterization. SEM and TEM images of (a) spores and (b) SC, respectively. The SEM and TEM images of (c) DS NPs and (d) SC@DS NPs, respectively. (e) The morphologies of DS NPs and SC@DS NPs were investigated after 2 h incubation in SGF. (f) The cumulative DOX and SOR release of DS NPs and SC@DS NPs in SGF. (g) The morphology changes of DS NPs and SC@DS NPs after 4 h incubation in SIF. (h) The cumulative release amount of SOR and DOX in DS NPs and SC@DS NPs groups after being incubated in SIF for 4 h. (i) The release behavior of drugs from DS NPs and SC@DS NPs after being incubated in a buffer with gradually varying pH for over 24 h. (j) The percentage of particles-mucin aggregation formed in simulated mucus solution for different preparations at 37℃Back to article page