Fig. 2

Evaluation of the mechanism of BSO@MOF-L-induced cell death. a Schematic illustration of ferroptosis and related ferroptotic regulators. b Cell viability of 4T1 cells after treatment with different concentrations of the nanoparticles (n = 4). c–h Cell viability of 4T1 cells after treatment with BSO@MOF-L and c Fer-1, d GSH, e VE, f Glu, g Necrostain-1, or h 3-methyladenine (c–f, n = 5; g-h, n = 4). * p < 0.05, ** p < 0.01. Fer-1, ferrostatin-1; GSH glutathione; VE vitamin E; Glu glutamate; ROS reactive oxygen species; LPO lipid peroxides; GPX4 glutathione peroxidase 4; LOH lipid alcohols