Scheme 1.
Schematic illustration of the preparation of BSO&OXA@MOF-LR for ferroptosis/apoptosis-based cancer therapy. a Synthesis of BSO&OXA@MOF-LR. b The mechanism of BSO&OXA@MOF-LR action for tumor therapy, which is achieved by inducing both ferroptosis and apoptosis. MOF metal-organic framework; BSO buthionine sulfoxide amine; OXA oxaliplatin; RGD arginine-glycine-aspartic acid; ROS reactive oxygen species; GPX4 glutathione peroxidase 4; GSH glutathione; GSSG oxidized glutathione