Fig. 1
Characterization of nano ZIF-8. (A) SEM, (B) TEM, (C) Statistics of size, (D) PXRD, (E) FT-IR, (F) toxicological evaluation. Different concentrations (0, 5, 10, 20, 50 and 100 µg/ml) of ZIF-8 were added to DPSC for CCK-8 detection at 24,48 and 96 h (G) Intracellular trafficking of C6-labeled ZIF-8 (20 µg/ml; green fluorescence) in DPSCs. LysoTracker (red) was used to label the lysosome, and Hoechst 33,342 (blue) was used to label the nucleus. (H) Quantification of the relative fluorescence intensity of C6-labeled ZIF-8. ***P < 0.001. (I) ZIF-8 nanoparticles were dispersed in α-MEM with different PH values, and Zn2+ levels were detected at different time points