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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Metal-organic framework materials promote neural differentiation of dental pulp stem cells in spinal cord injury

Fig. 8

Schematic diagram of ZIF-8 combined with DPSCs to repair spinal cord injury. Loss of Zn2+ at the site of spinal cord injury leads to apoptosis of local transplanted stem cells and neurons. ZIF-8 slowly releases Zn2+ in DPSCs, helping to resist apoptosis induced by Zn deprivation. In addition, Zn2+ promotes the phosphorylation of JNK1 to upregulate the expression of βIII-tubulin, and promotes the neural differentiation of DPSCs. Phosphorylation of P38 also leads to increased expression of VEGF-a and promotes angiogenesis

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Journal of Nanobiotechnology

ISSN: 1477-3155

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