Fig. 1

Schematic illustration of the mineralization process of ZIF-8 for enhancing bone regeneration. a) ZIF-8 mineralization under humoral environment. Ca attack induced ZIF-8 degradation, and this provided the Ca-P binding sites and caused apatite deposition. b) Mineralized ZIF-8/PCL scaffold prepared through melt electrowritten printing was implanted in the rat critical-sized skull defect to evaluate the bone regeneration enhancement effect. c) Hypothetical chemical reaction equations used to calculate ZIF-8 mineralization