Fig. 8

In vivo evaluation of new bone formation. a) Macroscopic observation of implantation area intraoperatively. b) Micro-CT 3D reconstruction images showing Ca bone defects at 4- and 12-week after implantation of mPCL and mZIF-8/PCL. Purple lines represent original cranial defect boundary. mZIF-8/PCL group had a greater number of new bones than the rest groups. Quantification of c) BV, d) BV/TV and e) BMD based on micro-CT analysis. * p < 0.05, ** p < 0.01, *** p < 0.001, ns: not significant (n = 8)