Fig. 9
a The tumor growth curves of mice were intravenously treated with PBS, Lenvatinib (100 mg kg−1), AQ4N (5 mg kg−1), IR 780 (5 mg kg−1), and ILA@Lip (AQ4N: 5 mg kg−1, Lenvatinib: 100 mg kg−1, IR 780: 5 mg kg−1) with or without laser irradiation every 2 days for 3 cycles. Values represent means ± SD, n = 4. ***P < 0.001 vs control. b Body weight changes during the experiment. Values represent means ± SD, n = 4. Hepatic and renal function test of c ALT, d) AST, e BUN, and f CR. Values represent means ± SD, n = 4. g Immunofluorescence images and h Quantification for CD31 staining in 4T1 tumors of mice with different formulations at the experimental endpoint. Scale bar = 100 μm. Values represent means ± SD, n = 4. i Immunofluorescence images and j Quantification for HIF-1α staining in 4T1 tumors of mice with different formulations at the experimental endpoint. Scale bar = 50 μm. Values represent means ± SD, n = 4