Fig. 1
From: New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery
The glial-lymphatic pathway and lymphatic uptake of brain. The meningeal structure of the brain contains dura mater, arachnoid, and pie mater. The meningeal lymphatic vessels are mainly responsible for immunogen uptake. With the arterial pulsation, CSF in the subarachnoid space enters the deep part of the brain parenchyma along the PVS and rapidly enters the brain parenchyma through the rapid transport by AQP4 distributed on the end foot of astrocytes, then returns through the PVS, and finally enters the dural lymphatic vessels