Fig. 3
From: New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery
LN targeted drug delivery optimalizes the antigen presentation process. The neoantigens released by tumor were taken by mLVs via the glial-lymphatic pathway. Subsequently, neoantigens were drained to the cLNS and activated the APC and naive T cells within them. As a contrast, LN targeted drug delivery can bypass the above complex links, directly and efficiently activate APC and T cells, and greatly enhance the immune response