Skip to main content
Scheme 1 | Journal of Nanobiotechnology

Scheme 1

From: Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade

Scheme 1

Schematic illustration of the DSNP-mediated improvement of the anti-inflammatory effect of garcinol in a mouse CIA model. DSNPs improved the anti-inflammatory effect of garcinol through several mechanisms: (1) garcinol was effectively loaded into the DSNPs; (2) the DSNPs were selectively taken up by activated macrophages via scavenger receptor class A-mediated endocytosis and effectively accumulated in inflamed joints; and (3) DSNPs enabled the release of garcinol at the intracellular regions of the inflamed site, thereby enhancing the anti-arthritic effect and avoiding the side effects of garcinol. The graphical abstract was created with BioRender.com

Back to article page

Journal of Nanobiotechnology

ISSN: 1477-3155

Contact us