From: The current status of stimuli-responsive nanotechnologies on orthopedic titanium implant surfaces
Response system | Magnetic field type | Preparation processes | Responding mechanism | Drug delivery | Main results |
---|---|---|---|---|---|
Magnetically responsive TNT delivery system (Aw2012 [13]) | External permanent magnet | 1. TNT was prepared through EA 2. Dopa-Fe3O4 magnetic nanoparticles are loaded at the bottom of TNT 3. Micellar coated Ind was loaded on the upper end of magnetic nanoparticles | Magnetically drives magnetic nanoparticles from the bottom | Preloading drugs in TNT | Achieve drugs-controlled release of magnetic response |
MNPSNPs (Janßen2018 [14]) | EM field/1.8 T/10 min | 1. Fe3O4 is loaded with mesoporous silica 2. Fluorescein FIEC and RIBC are attached to the surface 3. Peg-silane modification 4. Nanoparticles are loaded onto Ti surface | Electromagnetic response property of Fe3O4 | Tail vein injection | 1. Good drug targeting 2. Good biocompatibility |
Superparamagnetic PLGA coating (Ag–Fe3O4) (Yang2018 [17]) | Permanent magnet is embedded in dental implants | Ag–Fe3O4 nanoparticles are loaded with PLGA coating on Ti surface | Magnetic adsorption magnetic particles; antibacterial activity of Ag ions | Nano-coating | 1. The fixed PLGA 2. Good antibacterial activity 3. Promote the proliferation of bone cells |
Superparamagnetic TiO2 coating (Li2019 [139]) | – | Fe3O4 modified TiO2 coating | Effect of micromagnetic field on fibroblast | Nano-coating | 1. Inhibit bacterial adhesion and reproduction 2. Improve soft tissue integration |