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Table 1 Magnetic responsive nanotechnology designs

From: The current status of stimuli-responsive nanotechnologies on orthopedic titanium implant surfaces

Response system

Magnetic field type

Preparation processes

Responding mechanism

Drug delivery

Main results

Magnetically responsive TNT delivery system (Aw2012 [13])

External permanent magnet

1. TNT was prepared through EA

2. Dopa-Fe3O4 magnetic nanoparticles are loaded at the bottom of TNT

3. Micellar coated Ind was loaded on the upper end of magnetic nanoparticles

Magnetically drives magnetic nanoparticles from the bottom

Preloading drugs in TNT

Achieve drugs-controlled release of magnetic response

MNPSNPs (Janßen2018 [14])

EM field/1.8 T/10 min

1. Fe3O4 is loaded with mesoporous silica

2. Fluorescein FIEC and RIBC are attached to the surface

3. Peg-silane modification

4. Nanoparticles are loaded onto Ti surface

Electromagnetic response property of Fe3O4

Tail vein injection

1. Good drug targeting

2. Good biocompatibility

Superparamagnetic PLGA coating (Ag–Fe3O4) (Yang2018 [17])

Permanent magnet is embedded in dental implants

Ag–Fe3O4 nanoparticles are loaded with PLGA coating on Ti surface

Magnetic adsorption magnetic particles; antibacterial activity of Ag ions

Nano-coating

1. The fixed PLGA

2. Good antibacterial activity

3. Promote the proliferation of bone cells

Superparamagnetic TiO2 coating (Li2019 [139])

–

Fe3O4 modified TiO2 coating

Effect of micromagnetic field on fibroblast

Nano-coating

1. Inhibit bacterial adhesion and reproduction

2. Improve soft tissue integration