Fig. 2

Subgroup analysis of the patients with CSC according to the treatment response to intravitreal anti-VEGFs. A Representative wide-field fundus, autofluorescence images, and optical coherence tomography (OCT) of patients with CSC depending on the anti-VEGF treatment response. B, C Quantification of the changes to the OCT parameters; central retinal thickness (CRT), subfoveal choroidal thickness (SFChT), and subretinal fluid (SRF) height changes were measured. (n = 17, responder [CSC-R]; n = 25, non-responder [CSC-NR]). D, E Scatter plots show the difference in the expression of miRNAs between control and CSC-R (D) and CSC-NR (E). The red-dotted line indicates twofold changes. NS for no statistical significance. F Heatmap of unsupervised hierarchical clustering. (G) Heatmap of differential miRNA expression between CSC-R and CSC-NR. (H) Relative miRNA expression in AH-derived exosomes from controls or patients with CSC-R or CSC-NR