Fig. 6

STC2 is a potential target for miR-184 regulating angiogenesis, vasculogenesis, motility, and choroidal endothelial cell proliferation. A Venn diagram showing miR-184 target gene prediction results of TargetScan, miRDIP, and DIANA database. B Target gene interaction network for miRNAs enriched in the exosome of AH in patients with CSC. STC2 and miR-184 are highlighted. C Chord diagram showing the target genes of miR-184 and linking between enriched biological processes (by colors). D Prediction of miR-184 binding sites in the 3’-UTR of human STC2 mRNA. E The STC2 mRNA was quantified in miR-184 mimic/inhibitor transfected hCEC 24 h after transfection. Four independent culture replicates with two amplification replicates were performed. F-G The STC2 protein in miR-184 mimic/inhibitor transfected was quantified by western blotting 48 h after transfection. Three independent culture replicates with two SDS-page replicates were performed. The graph values are represented as mean ± standard deviation. ^* P < 0.05, ^** P < 0.01 (all n = 3)