Fig. 6
GNRs@PEG-Iso4 binds to orthotopic MB49-Luc bladder tumors but not to healthy bladder tissue. Representative axial 2D PA and US images of the bladder from tumor-bearing mice (n = 4 mice) or from healthy control mice (n = 2 mice) before and after the instillation of GNRs@PEG-Iso4 (26 nmol Au, ~ 1 × 1011 NPs), followed by incubation and bladder washing. Tumor-bearing mice were PA and US imaged 11–14 days after MB49-Luc cell implantation. Grayscale, co-registered US signal; Green, PA signal. Cyan arrows, PA signal generated by GNRs@PEG-Iso4. Yellow arrows, PA signal independent of GNRs@PEG-Iso4. Bar, 2 mm