Fig. 7.

3D PA and US images of bladders from MB49-Luc tumor-bearing mice or healthy control mice before and after instillation of GNRs@PEG-Iso4. Representative 3D visualization (left and middle panels) and 3D reconstruction (right panels) of the PA and US signal of the bladders of mice of Fig. 6. Grayscale, co-registered ultrasound signal; Green, PA signal. Cyan arrows, specific signal of GNRs@PEG-Iso4. Yellow arrows, nonspecific signal recorded outside the bladder present before administration of GNRs@PEG-Iso4. Note the almost complete absence of PA signal inside the bladder in control animals. Red arrows indicate small spots of PA signal likely corresponding to small bladder cancer lesions (< 0.5 mm) that are undetectable by standard US echography