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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Conversion of senescent cartilage into a pro-chondrogenic microenvironment with antibody-functionalized copper sulfate nanoparticles for efficient osteoarthritis therapy

Fig. 4

Apoptosis of senescent chondrocytes induced by B2M-CuS NPs. (a) Representative fluorescence images of total intracellular ROS in senescent chondrocytes after co-culturing with NPs (50 µg mL− 1) for 24 h. (b) Representative fluorescence images of mitochondrial ROS in senescent chondrocytes following treatment. (c) Quantitative analysis of the relative fluorescence intensity of total ROS derived from (a). (d) Quantitative analysis of the relative fluorescence intensity of mitochondrial ROS derived from (b). (e-i) Relative mRNA expression of Bcl-2, Bax, Bax/Bcl-2, Caspase-3, and Caspase-9 in senescent chondrocytes following treatment (n = 3). (j) Quantitative analysis of apoptosis in senescent chondrocytes following treatment. (k) Quantitative analysis of 7-AAD positive cells in different groups. Data are presented as mean ± SD (n = 3). *p<0.05, **p<0.01, ***p<0.001, and ****p<0.0001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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