Table 1 In vivo Nanotechnology-based Scaffold in skin scarring

Aligned carbon nanotubes (ACNTs) film

—

Rabbit ear model of hypertrophic scars (HS)

Ideal inhibitory effect on HS; suppressing cell proliferation, and guiding growth direction

[40]

Polycaprolactone(PCL) based electrospun nanofibrous mats (ENMs)

α-lactalbumin(ALA)

Rat deep second-degree burn model

Reduction of scar formation; accelerated wound healing and anti-inflammatory effects

[41]

Anisotropic Silver Nanoparticles (AgNPs) loaded Composite chitosan(Ch) electrospun nanofiber

Cur

Rat full-thickness skin wound model

Less scar formation; promotion of wound healing and antibacterial activity

[42]

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibrous meshes

—

Mouse full-thickness skin wound model

Mitigated excessive scar formation; improved re-epithelization and mitigated wound contraction

[43]

Cellulose acetate (CA)/soy protein hydrolysate (SPH) nanofibers scaffolds

—

Mouse excisional wound splinting model

Reduced scar formation; accelerated wound closure and tissue regeneration

[44]

Bilayer membranous (BLM) nanofiber scaffold

Decellular dermis matrix

Rabbit ear wound model

Inhibit the formation of hypertrophic scars; inhibit collagen fiber deposition and angiogenesis

[45]

Functionalized electrospun double-layer nanofibrous scaffold

Quaternized chitosan and silicone

Rabbit ear wound model

Inhibits scar formation, resists bacteria, promotes wound healing

[46]

Poly(ε-caprolactone)/gelatin (Gel) nanofibrous scaffolds (PCL/GE/PALs)

Palmatine

Rabbit ear model of HS

Significantly inhibition of HS formation; accelerated wound healing, decreased density of microvascular

[47]

Electrospun poly (L-lactide-co-glycolide)/gelatin (PLGA/Gel) membranes

ZnO nanoparticles and liraglutide

Rat bacterial-infected wound model

Scar length reduction; fast wound healing rate and antibacterial effect

[48]

Electrospun nanofibrous silk fibroin (SF)/GEL electrospun nanofiber

Astragaloside IV

Rat acute wound model

Anti-scar effect; accelerated healing, enhanced angiogenesis, and arrangement of collagen

[49]

Nanofibrous Electrospun Heart Decellularized Extracellular Matrix-based Hybrid Scaffold(NEhdHS)

—

Rat full-thickness skin wound model

Reduced scarring in the wound healing process

[50]

Rg3-loaded nanoin-micro electrospun composite fibers

20 S-Ginsenoside Rg3 (Rg3)

Rabbit ear model of HS

Inhibition of HS formation; reduced collagen deposition and vascularization; more sustainable drug release

[51]

PLGA nanoparticles in polyethylene glycol diacrylate (PEGDA) core/alginate shell structured hydrogel particles

hydrophobic corticosteroid

Rabbit ear wound model

Exhibited suppress scar formation; sustainable drug release over 4 weeks

[52]

Cerium oxide (CeO₂) nanocapsules (NCs) Adhered plasma-etched polylactic acid (PLA)-fiber membranes

Pirfenidone(PFD)

Mouse wound-healing odel

Satisfactory wound-repairing and anti-scarring effects

[53]

Cerium oxide nanoparticles (CONPs)-loaded Poly-L-lactic acid (PLLA)-gelatin composite fiber membranes

—

Rats scalding model

Better scar remodeling effect and regenerative performance compared to other groups

[54]